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Se hela listan på hindawi.com Salinomycin is a monocarboxylic polyether antibiotic with unique tricyclic spiroketal ring systems and an unsaturated six-membered ring in the molecule. Salinomycin has antimicrobial and anticoccidial activities. It is an alkali ion carrier with affinity for cations and preference for K + over other monovalent and divalent cations. 2015-02-06 · Although these two kinases are very similar in sequence and structure, they can often have differential effects on the activation of p38 . Our data in human fibroblasts show that the expression and activation of a constitutively active MKK6 attenuate the effect of salinomycin on p38 and myofibroblast formation (Fig.

Salinomycin structure

According to a classification scheme(2), this estimated Koc value suggests that salinomycin is expected to be immobile in soil. Structure, properties, spectra, suppliers and links for: Salinomycin, 53003-10-4. Salinomycin is the key compound in the pharmaceutical company Verastem's efforts to produce an anti-cancer-stem-cell drug. Use in agriculture. Salinomycin is used in chicken feed as a coccidiostat.

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Salinomycin. 2 Product Results. | Match Criteria: Product Name, Property, Description. Empirical Formula (Hill Notation): C42H70O11.

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Salinomycin has been shown by Piyush Gupta et al. of the Massachusetts Institute of Technology and the Broad Institute to kill breast cancer stem cells in mice at least 100 times more effectively than the anti-cancer drug paclitaxel.

CAS No.: 53003-10-4. synonymer: procoxacin | salinomycin premix 12% | salinomycin The Molecular Basis for Inhibition of Stemlike Cancer Cells by Salinomycin. Structure-Activity Relationships in Salinomycin: Cytotoxicity and Phenotype Borgström, Björn (author); Salinomycin analogs : Mechanistic probes and structure–activity relationships against cancer stem cells; Doctoral thesis (other Influence of salinomycin treatment on division and movement of individual cancer Authors show that MBP is acutely toxic by destroying mitochondria structure Nielsen, H. Luthman: Structure and localization of the human insulin-like growth factor- binding protein salinomycin on cancer cell lines and cancer stem cells.
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Författare :Björn Borgström; Centrum för analys och The thesis title is 'On the Breast Cancer Stem Cell Selectivity of Salinomycin and its Structural Analogues'. During the PhD study, I mainly focused on the effect of Swedish University dissertations (essays) about STRUCTURE–ACTIVITY. Salinomycin analogs : Mechanistic probes and structure–activity relationships 1. Challenges of urban nature conservation · 2. Salinomycin analogs : Mechanistic probes and structure–activity relationships against cancer stem cells · 3.

2016-03-14 · Salinomycin diastereoisomers and their benzoylated derivatives were synthesized and evaluated for both antiproliferative activity and neurotoxicity in vitro. The results indicated that the stereoscopic configurations of the spiro C17 and C21 atoms as well as the benzoyl groups of O-20 on the rigid B/C/D spiro-ketal structures are crucial for biological activity and neural toxicity. 2017-03-28 · Salinomycin blocked Wnt signaling and downregulated ZEB1, thereby increasing the sensitivity of MCL cells to the cytotoxic effect of gemcitabine, cytarabine, and doxorubicin. 70 In combination with metformin, salinomycin was able to block TGFβ-induced EMT and inhibit EMT-induced cell migration in the two non-small-cell lung cancer cell lines A549 and HCC4006.
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1 Treatment of 5 mg For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from PDBe, to allow us to map Pfam domains onto UniProt three-dimensional structures.The table below shows the sequences and Pfam domains that correspond to this structure. To the best of our knowledge until now no information on the ability of salinomycin to form complexes with Cd(II), Pb(II) and Hg(II) has been published. In the present paper we report for the first time the preparation and the structure characterization of salinomycin complexes with ions of … 2011-09-09 Search results for salinomycin751005300310411 at Sigma-Aldrich. Compare Products: Select up to 4 products. *Please select more than one item to compare chemBlink provides information on suppliers of Salinomycin (CAS # 53003-10-4) If submitting your inquiry to a single supplier, click Inquire for this suplier. If submitting your inquiry to multiple suppliers, .

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Colorless gas. Ball-and-stick model, geometric structure and structural . salinomycin och monensin är fortfarande tillåtna men föreslås av Soil compaction processes and their effects on the structure of arable soils and the. Using a structure estimation method based on molecular connectivity indices(1), the Koc of salinomycin can be estimated to be 6050(SRC). According to a classification scheme(2), this estimated Koc value suggests that salinomycin is expected to be immobile in soil.

Sacox® is intended to be incorporated into feedingstuffs directly and/or through premixtures. The properties of salinomycin is highlighted by a significant loss of activity by modifications directly interfering with either of the two primary ion coordinating motifs in salinomycin, the C11 ketone and the C1 carboxylate. Introduction Phenotypic heterogeneity within tumors has emerged as a key Structure, properties, spectra, suppliers and links for: Salinomycin sodium. Our findings suggest that targeting UM CSCs by salinomycin is a promising therapeutic strategy to hamper hepatic metastasis in UM. These results provide the first pre-clinical evidence for further testing of salinomycin for its antitumor efficacy in UM patients with hepatic metastasis. Salinomycin sodium salt(55721-31-8) Reference standards for Pharmacological research. IC50: 7.7, 13.7 and 10.4 μM for HepG2, SMMC-7721 and BEL-7402 cell line, respectively (after 24h treatment)Salinomycin (Sal) sodi 2019-11-13 · Salinomycin counteracts the proliferation of uveal melanoma cells.